Neurons in the monkey orbitofrontal cortex mediate reward value computation and decision-making

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作者
Tsuyoshi Setogawa
Takashi Mizuhiki
Narihisa Matsumoto
Fumika Akizawa
Ryosuke Kuboki
Barry J. Richmond
Munetaka Shidara
机构
[1] University of Tsukuba,Faculty of Medicine
[2] National Institutes of Health,Department of Health and Human Services, Laboratory of Neuropsychology, National Institute of Mental Health
[3] University of Tsukuba,Doctoral Program in Kansei, Behavioral and Brain Science, Graduate School of Comprehensive Human Sciences
[4] Human Informatics Research Institute,undefined
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Communications Biology | / 2卷
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Choice reflects the values of available alternatives; more valuable options are chosen more often than less valuable ones. Here we studied whether neuronal responses in orbitofrontal cortex (OFC) reflect the value difference between options, and whether there is a causal link between OFC neuronal activity and choice. Using a decision-making task where two visual stimuli were presented sequentially, each signifying a value, we showed that when the second stimulus appears many neurons encode the value difference between alternatives. Later when the choice occurs, that difference signal disappears and a signal indicating the chosen value emerges. Pharmacological inactivation of OFC neurons coding for choice-related values increases the monkey’s latency to make a choice and the likelihood that it will choose the less valuable alternative, when the value difference is small. Thus, OFC neurons code for value information that could be used to directly influence choice.
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