Inhibitor Analysis of Cholinesterases of Different Origin (Variation of Structure of Leaving Group of Organophosphorus Inhibitors)

There is presented an analytic review of literature data on inhibitory analysis of structure of cholinesterases of different animals (vertebrates, insects, and molluscs) performed by studying rate of their interaction with 64 organophosphorus compounds of 13 series with different structure of leaving group. The presented data are considered from the point of view of comparative biochemistry and in the light of current data on structure of the cholinesterase active center.