Role of ferroptosis and ferroptosis-related long non'coding RNA in breast cancer

被引：0
作者：
Shasha Xiang
Wen Yan
Xing Ren
Jianbo Feng
Xuyu Zu
机构：
[1] University of South China,Cancer Research Institute, The First Affiliated Hospital, Hengyang Medical School
[2] University of South China,Department of Clinical Laboratory Medicine, The First Affiliated Hospital, Hengyang Medical School
来源：
Cellular & Molecular Biology Letters | / 29卷
关键词：
LncRNA; Breast cancer; Ferroptosis; Ferroptosis-related lncRNA; Biomarker;
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摘要：
Ferroptosis, a therapeutic strategy for tumours, is a regulated cell death characterised by the increased accumulation of iron-dependent lipid peroxides (LPO). Tumour-associated long non-coding RNAs (lncRNAs), when combined with traditional anti-cancer medicines or radiotherapy, can improve efficacy and decrease mortality in cancer. Investigating the role of ferroptosis-related lncRNAs may help strategise new therapeutic options for breast cancer (BC). Herein, we briefly discuss the genes and pathways of ferroptosis involved in iron and reactive oxygen species (ROS) metabolism, including the XC−/GSH/GPX4 system, ACSL4/LPCAT3/15-LOX and FSP1/CoQ10/NAD(P)H pathways, and investigate the correlation between ferroptosis and LncRNA in BC to determine possible biomarkers related to ferroptosis.
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