Orally active insulin mimics: where do we stand now?

被引：0
作者：
M. Balasubramanyam
V. Mohan
机构：
[1] Madras Diabetes Research Foundation (MDRF),
来源：
Journal of Biosciences | 2001年 / 26卷
关键词：
Insulin mimetic; insulin receptor tyrosine kinase; PI 3-kinase; vanadium;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The war against diabetes through the development of new drugs is an ongoing continuous process to counter the alarming global increase in the prevalence of diabetes and its complications, particularly in developing countries like India. Unfortunately, the speed with which our knowledge of diabetes and its effects is expanding is not matched by the availability of new drugs. Following the identification of the insulin receptor (IR), its intrinsic kinase activity and molecular cloning, many studies have looked at IR as an ideal drug target. This review summarizes in brief the latest advancements in this field with particular reference to the current situation in respect of the development of orally active insulin mimetics in the treatment of type 2 diabetes.
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页码：383 / 390
页数：7
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  • [51] Thomas F(2000)New azolidine-diones as inhibitors of protein tyrosine phosphatase 1B with antihyperglycemic properties Pharm. Res. 17 1468-1474
  • [52] Jenquin M(1987)Oral peptide drug delivery: polymer-inhibitor conjugates protecting insulin from enzymatic degradation in vitro J. Biol. Chem. 263 6658-6662
  • [53] Silverman J F(2001)Design and Nature (London) 379 840-844
  • [54] Khazanie P G(1995) evaluation of an oral delivery system for insulin Diab. Res. Clin. Pract. 28 S115-137
  • [55] Sinha M K(2000)Oral administration of vanadate normalizes blood glucose levels in streptozotocin-treated rats Mol. Med. 6 907-933
  • [56] Caro J F(1976)Insulin action impaired by deficiency of the G-protein subunit Gialpha2 J. Clin. Invest. 57 1165-1172
  • [57] Sinha M(1994)Extrapancreatic effects of sulfonylureas — a comparison between glimepiride and conventional sulfonylureas J. Biol. Chem. 269 4596-4604
  • [58] Raju S M(1995)The molecular mechanisms of the insulin-mimetic/sensitizing activity of the antidiabetic sulfonylurea drug Amaryl Mol. Cell. Biol. 15 5403-5411
  • [59] Itoop O(2000)Decreased insulin binding to adipocytes and circulating monocytes from obese subjects J. Biol. Chem. 275 36590-36595
  • [60] Pories W J.(1983)Peroxovanadium compounds. A new class of potent phosphotyrosine phosphatase inhibitors which are insulin mimetics Proc. Natl. Acad. Sci. USA 80 3237-3240
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