Targeted genome editing in primate embryos

被引：0

作者：

Xiangyu Guo

Xiao-Jiang Li

机构：

[1] Institute of Genetics and Developmental Biology,Department of Human Genetics

[2] Chinese Academy of Sciences,undefined

[3] Emory University School of Medicine,undefined

来源：

Cell Research | 2015年 / 25卷

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摘要：

Mosaic mutations and off-target effects caused by CRISPR/Cas9 have led to concerns about the efficiency and specificity of this new technique in non-human primates and other large animals. Here we discuss recent findings from primate embryos, with a focus on the technical issues CRISPR/Cas9 faces before producing non-human primate models of human diseases.

引用

页码：767 / 768

页数：1