Preparation and in Vitro/in Vivo Evaluation of Insulin-Loaded Poly(Acryloyl-Hydroxyethyl Starch)-PLGA Composite Microspheres

被引:0
|
作者
Ge Jiang
Wei Qiu
Patrick P. DeLuca
机构
[1] University of Kentucky ,Pharmaceutical Sciences
[2] College of Pharmacy,undefined
来源
Pharmaceutical Research | 2003年 / 20卷
关键词
PLGA; hydroxyethyl starch; microsphere; insulin; controlled release;
D O I
暂无
中图分类号
学科分类号
摘要
Purpose. The purpose of this study was to develop and evaluate a novel composite microsphere delivery system composed of poly(D,L-lactide-co-glycolide) (PLGA) and poly(acryloyl hydroxyethyl starch) (acryloyl derivatized HES; AcHES) hydrogel using bovine insulin as a model therapeutic protein.
引用
收藏
页码:452 / 459
页数:7
相关论文
共 35 条
  • [21] PLGA sustained-release microspheres loaded with an insoluble small-molecule drug: microfluidic-based preparation, optimization, characterization, and evaluation in vitro and in vivo
    Su, Yue
    Liu, Jia
    Tan, Songwen
    Liu, Wenfang
    Wang, Rongrong
    Chen, Chuanpin
    DRUG DELIVERY, 2022, 29 (01) : 1437 - 1446
  • [22] Preparation, in vitro and in vivo evaluation of PLGA/Chitosan based nano-complex as a novel insulin delivery formulation
    Mohammadpour, Fatemeh
    Hadizadeh, Farzin
    Tafaghodi, Mohsen
    Sadri, Kayvan
    Mohammadpour, Amir Hooshang
    Kalani, Mohammad Reza
    Gholami, Leila
    Mahmoudi, Asma
    Chamani, Jamshidkhan
    INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2019, 572
  • [23] Development of lovastatin-loaded poly(lactic acid) microspheres for sustained oral delivery: in vitro and ex vivo evaluation
    Guan, Qigang
    Chen, Wei
    Hu, Xianming
    DRUG DESIGN DEVELOPMENT AND THERAPY, 2015, 9 : 791 - 798
  • [24] Preparation and in vitro in vivo evaluation of aceclofenac loaded alginate microspheres: An investigation of effects of polymer using multiple comparison analysis
    Khandai, Madhusmruti
    Chakraborty, Santanu
    Nayak, Priyanka
    Krishna, N. Bala Murali
    Chakravarthi, Gandepalli
    Acharjya, Biswajit
    Ghosh, Ashoke Kumar
    CURRENT DRUG DELIVERY, 2012, 9 (05) : 495 - 505
  • [25] Biodegradable nanoparticles loaded with insulin-phospholipid complex for oral delivery: Preparation, in vitro characterization and in vivo evaluation
    Cui, Fude
    Shi, Kai
    Zhang, Liqiang
    Tao, Anjin
    Kawashima, Yoshiaki
    JOURNAL OF CONTROLLED RELEASE, 2006, 114 (02) : 242 - 250
  • [26] Incorporation of salmon calcitonin-loaded poly(lactide-co-glycolide) (PLGA) microspheres into calcium phosphate bone cement and the biocompatibility evaluation in vitro
    Zhong, Mei-Ling
    Chen, Xiao-Qin
    Fan, Hong-Song
    Zhang, Xing-Dong
    JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS, 2012, 27 (02) : 133 - 147
  • [27] Entecavir-loaded poly (lactic-co-glycolic acid) microspheres for long-term therapy of chronic hepatitis-B: Preparation and in vitro and in vivo evaluation
    Zhang, Chunyan
    Wang, Aiping
    Wang, Huiyun
    Yan, Maocai
    Liang, Rongcai
    He, Xiuting
    Fu, Fenghua
    Mu, Hongjie
    Sun, Kaoxiang
    INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2019, 560 : 27 - 34
  • [28] Preparation and in vitro/in vivo evaluation of doxorubicin-loaded poly [lactic-co-glycol acid] microspheres using electrospray method for sustained drug delivery and potential intratumoral injection
    Hsu, Ming-Yi
    Huang, Yu-Ting
    Weng, Chun-Jui
    Chen, Chien-Ming
    Su, Yong-Fong
    Chu, Sung-Yu
    Tseng, Jeng-Hwei
    Wu, Ren-Chin
    Liu, Shih-Jung
    COLLOIDS AND SURFACES B-BIOINTERFACES, 2020, 190
  • [29] Fabrication and characterisation of curcumin loaded pH dependent sodium alginate-g-poly(acryloyl phenylalanine)-cl-ethylene glycol vinyl ether-co-hydroxyethyl acrylate hydrogels and their in-vitro, in-vivo and toxicological evaluation studies
    Rudhrabatla, V. S. A. Pavan
    Jalababu, R.
    Rao, K. S. V. Krishna
    Reddy, K. V. N. Suresh
    JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, 2019, 51 : 438 - 453
  • [30] In vitro drug release and antibacterial activity evaluation of silk fibroin coated vancomycin hydrochloride loaded poly (lactic-co-glycolic acid) (PLGA) sustained release microspheres
    Li, Shengtang
    Shi, Xuewen
    Xu, Bo
    Wang, Jian
    Li, Peng
    Wang, Xin
    Lou, Jinpeng
    Li, Ziyao
    Yang, Chengwei
    Li, Songkai
    Zhen, Ping
    JOURNAL OF BIOMATERIALS APPLICATIONS, 2022, 36 (09) : 1676 - 1688