Brain 5-HT2A receptor binding and its neural network related to behavioral inhibition system

被引：0

作者：

Kazuho Kojima

Shigeki Hirano

Yasuyuki Kimura

Chie Seki

Yoko Ikoma

Keisuke Takahata

Takehito Ito

Keita Yokokawa

Hiroki Hashimoto

Kazunori Kawamura

Ming-Rong Zhang

Hiroshi Ito

Makoto Higuchi

Satoshi Kuwabara

Tetsuya Suhara

Makiko Yamada

机构：

[1] Chiba University,Department of Neurology, Graduate School of Medicine

[2] National Institutes for Quantum Science and Technology,Department of Functional Brain Imaging, Institute for Quantum Medical Science

[3] Department of Clinical and Experimental Neuroimaging,Department of Molecular Imaging and Theranostics, Institute for Quantum Medical Science

[4] Center for Development of Advanced Medicine for Dementia,Department of Advanced Nuclear Medicine Sciences, Institute for Quantum Medical Science

[5] National Center for Geriatrics and Gerontology,Department of Radiology and Nuclear Medicine

[6] National Institutes for Quantum Science and Technology,Institute for Quantum Life Science

[7] National Institutes for Quantum Science and Technology,undefined

[8] Fukushima Medical University,undefined

[9] National Institutes for Quantum Science and Technology,undefined

来源：

Brain Imaging and Behavior | 2022年 / 16卷

关键词：

Behavioral inhibition system; Serotonin system; Cingulate cortex; Positron emission tomography; Resting state functional magnetic resonance image;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

The tendency to avoid punishment, called behavioral inhibition system, is an essential aspect of motivational behavior. Behavioral inhibition system is related to negative affect, such as anxiety, depression and pain, but its neural basis has not yet been clarified. To clarify the association between individual variations in behavioral inhibition system and brain 5-HT2A receptor availability and specify which brain networks were involved in healthy male subjects, using [18F]altanserin positron emission tomography and resting-state functional magnetic resonance imaging. Behavioral inhibition system score negatively correlated with 5-HT2A receptor availability in anterior cingulate cortex. A statistical model indicated that the behavioral inhibition system score was associated with 5-HT2A receptor availability, which was mediated by the functional connectivity between anterior cingulate cortex and left middle frontal gyrus, both of which involved in the cognitive control of negative information processing. Individuals with high behavioral inhibition system displays low 5-HT2A receptor availability in anterior cingulate cortex and this cognitive control network links with prefrontal-cingulate integrity. These findings have implications for underlying the serotonergic basis of physiologies in aversion.

引用

页码：1337 / 1348

页数：11

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