FLT3: ITDoes matter in leukemia

被引：0
作者：
M Levis
D Small
机构：
[1] Johns Hopkins University School of Medicine,Department of Oncology
[2] Johns Hopkins University School of Medicine,Department of Pediatrics
来源：
Leukemia | 2003年 / 17卷
关键词：
FLT3; AML; ITD; receptor tyrosine kinase; tyrosine kinase inhibitor;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
FMS-like tyrosine kinase-3 (FLT3), a receptor tyrosine kinase, is important for the development of the hematopoietic and immune systems. Activating mutations of FLT3 are now recognized as the most common molecular abnormality in acute myeloid leukemia, and FLT3 mutations may play a role in other hematologic malignancies as well. The poor prognosis of patients harboring these mutations renders FLT3 an obvious target of therapy. This review summarizes the data on the molecular biology and clinical impact of FLT3 mutations, as well as the therapeutic potential of several small-molecule FLT3 inhibitors currently in development.
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页码：1738 / 1752
页数：14
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