Skeletal disproportion in glucocorticoid-treated boys with Duchenne muscular dystrophy

被引：0
作者：
Kung-Ting Kao
Shuko Joseph
Nadia Capaldi
Sarah Brown
Marina Di Marco
Jennifer Dunne
Iain Horrocks
Sheila Shepherd
Syed Faisal Ahmed
Sze Choong Wong
机构：
[1] Royal Hospital for Children,Developmental Endocrinology Research Group
[2] Royal Hospital for Children,Paediatric Neurosciences Research Group
[3] Queen Elizabeth University Hospital,Scottish Muscle Network
来源：
European Journal of Pediatrics | 2019年 / 178卷
关键词：
Body proportions; Leg length; Muscular dystrophy; Sitting height; Steroid;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
We aimed to compare body segment and bone lengths in glucocorticoid-treated boys with Duchenne muscular dystrophy (DMD) with healthy controls using dual-energy absorptiometry (DXA) images. Total height (Ht), sitting height (SH), leg length (LL) and bone lengths (femur, tibia) in boys with DMD and age-matched control boys were measured using DXA. Thirty boys with DMD (median age 10.0 years (6.1, 16.8)) were compared with 30 controls. SH in DMD was 3.3 cm lower (95% CI − 6.1, − 0.66; p = 0.016). LL in DMD was 7.3 cm lower (95% CI − 11.2, − 3.4; p < 0.0001). SH:LL of boys with DMD was higher by 0.08 (95% CI 0.04, 0.12; p < 0.0001). Femur length in DMD was 2.4 cm lower (95% CI − 4.6, − 0.12; p = 0.04), whereas tibial length in DMD was 4.8 cm lower (95% CI − 6.7, − 2.9; p < 0.0001). SH:LL was not associated with duration of glucocorticoid use (SH:LL β = 0.003, 95% CI − 0.01 to 0.002, p = 0.72).
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页码：633 / 640
页数：7
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