An autoinhibitory helix in the C-terminal region of phospholipase C-β mediates Gαq activation

被引：0
作者：
Angeline M Lyon
Valerie M Tesmer
Vishan D Dhamsania
David M Thal
Joanne Gutierrez
Shoaib Chowdhury
Krishna C Suddala
John K Northup
John J G Tesmer
机构：
[1] Life Sciences Institute,Department of Biophysics
[2] University of Michigan,Department of Pharmacology
[3] Laboratory of Cell Biology,undefined
[4] National Institute on Deafness and Other Communication Disorders,undefined
[5] US National Institutes of Health,undefined
[6] University of Michigan,undefined
[7] University of Michigan,undefined
来源：
Nature Structural & Molecular Biology | 2011年 / 18卷
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摘要：
By examining the structure of phospholipase C-β, an autoinhibitory helix that interacts with the catalytic core of this enzyme is now identified. Disrupting this interaction enhances basal activity and decreases stimulation by Gαq, supporting an allosteric mechanism for PLCβ activation through displacement of the autoinhibitory helix by Gαq.
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页码：999 / 1005
页数：6
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