The genetic relationship among Iranian ethnic groups: an anthropological view based on HLA class II gene polymorphism

被引：32
作者：
Farjadian, Shirin [1 ,2 ]
Ota, Massao [3 ]
Inoko, Hidetoshi [4 ]
Ghaderi, Abbas [1 ,5 ]
机构：
[1] Shiraz Univ Med Sci, Dept Immunol, Shiraz, Iran
[2] Shiraz Univ Med Sci, Allergy Res Ctr, Shiraz, Iran
[3] Shinshu Univ, Dept Legal Med, Sch Med, Nagano, Japan
[4] Toki Univ, Dept Basic Med & Mol Med, Sch Med, Kanagawa, Japan
[5] Shiraz Univ Med Sci, Inst Canc Res, Shiraz, Iran
来源：
MOLECULAR BIOLOGY REPORTS | 2009年 / 36卷 / 07期
关键词：
Anthropology; Ethnic groups; HLA polymorphism; Iran; ALLELE FREQUENCIES; MOLECULAR ANALYSIS; POPULATION; HAPLOTYPES; ORIGIN; HLA-DQB1; AFFINITIES; DIVERSITY; HLA-DRB1; SPAIN;
D O I：
10.1007/s11033-008-9403-4
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Highly polymorphic human leukocyte antigen (HLA) genes are considered as useful markers by molecular anthropologists to determine genetic relationship among populations. This review summarizes the results of molecular analyses of HLA class II gene polymorphism in 816 DNA samples from 11 Iranian ethnic groups. The genetic relationship of Iranians to Asians and Europeans has also been reported here. The results of this study revealed a close genetic relationship among Iranian subpopulations which were well separated from other Asian and European populations, however, a genetic similarity was observed among Iranians, Macedonians, Greeks, and Italians.
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页码：1943 / 1950
页数：8
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