Characterization of antimicrobial and hemolytic properties of short synthetic cationic lipopeptides based on QSAR/QSTR approach

被引：0
作者：
Katarzyna E. Greber
Krzesimir Ciura
Mariusz Belka
Piotr Kawczak
Joanna Nowakowska
Tomasz Bączek
Wiesław Sawicki
机构：
[1] Medical University of Gdańsk,Department of Physical Chemistry, Faculty of Pharmacy
[2] Medical University of Gdańsk,Department of Pharmaceutical Chemistry, Faculty of Pharmacy
来源：
Amino Acids | 2018年 / 50卷
关键词：
QSAR; QSRR; Antimicrobial lipopeptides; MIC; Hemolysis;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
In this study, we investigated the influence of molecular descriptors of cationic lipopeptides on their antimicrobial activity and hemolytic properties. The quantitative structure–activity relationship and quantitative structure–property relationship models were constructed. The antimicrobial, hemolytic and retention data were used as dependent variable and structural parameters as the independent ones. The obtained results suggest that the chromatographic indexes can be employed for prediction of antibacterial activity and that lipopeptides present nonspecific interaction between erythrocytes and bacterial membranes.
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页码：479 / 485
页数：6
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