Is there a causal nexus between COVID-19 infection, COVID-19 vaccination, and Guillain-Barré syndrome?

被引：0

作者：

Xiaoxiao Zheng

Yong Fang

Yanna Song

Shan Liu

Kangding Liu

Jie Zhu

Xiujuan Wu

机构：

[1] The First Hospital of Jilin University,Department of Neurology, Neuroscience Center

[2] Jilin University,Department of Neurology

[3] The Third Affiliated Hospital of Sun Yat-sen University,Department of Neurobiology, Care Sciences and Society

[4] The Second Hospital of Jilin University,undefined

[5] Jilin University,undefined

[6] Karolinska Institute,undefined

[7] Karolinska University Hospital,undefined

来源：

European Journal of Medical Research | / 28卷

关键词：

Guillain-Barré syndrome; SARS-CoV-2; COVID-19; Vaccination; Epidemiology;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Guillain-Barré syndrome (GBS) is an immune-mediated inflammatory polyradiculoneuropathy, which commonly leads to a very high level of neurological disability. Especially, after the global outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, the causation between GBS and SARS-CoV-2 infection and the coronavirus disease 2019 (COVID-19) vaccination have aroused widespread concern. In the review, we analyzed the impacts of SARS-CoV-2 infection and COVID-19 vaccination on GBS globally, aiming to further understand the characteristics of GBS associated with COVID-19. Based on the electrophysiological data, patients suffering from GBS related to COVID-19 manifested as an acute inflammatory demyelinating polyneuropathy (AIDP). Moreover, we summarized the current findings, which may evidence GBS linking to SARS-CoV-2 infection and COVID-19 vaccination, and discussed the underlying mechanisms whether and how the SARS-CoV-2 virus and COVID-19 vaccination can induce GBS and its variants.

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