Is there a causal nexus between COVID-19 infection, COVID-19 vaccination, and Guillain-Barré syndrome?

被引：0
作者：
Xiaoxiao Zheng
Yong Fang
Yanna Song
Shan Liu
Kangding Liu
Jie Zhu
Xiujuan Wu
机构：
[1] The First Hospital of Jilin University,Department of Neurology, Neuroscience Center
[2] Jilin University,Department of Neurology
[3] The Third Affiliated Hospital of Sun Yat-sen University,Department of Neurobiology, Care Sciences and Society
[4] The Second Hospital of Jilin University,undefined
[5] Jilin University,undefined
[6] Karolinska Institute,undefined
[7] Karolinska University Hospital,undefined
来源：
European Journal of Medical Research | / 28卷
关键词：
Guillain-Barré syndrome; SARS-CoV-2; COVID-19; Vaccination; Epidemiology;
D O I：
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学科分类号：
摘要：
Guillain-Barré syndrome (GBS) is an immune-mediated inflammatory polyradiculoneuropathy, which commonly leads to a very high level of neurological disability. Especially, after the global outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, the causation between GBS and SARS-CoV-2 infection and the coronavirus disease 2019 (COVID-19) vaccination have aroused widespread concern. In the review, we analyzed the impacts of SARS-CoV-2 infection and COVID-19 vaccination on GBS globally, aiming to further understand the characteristics of GBS associated with COVID-19. Based on the electrophysiological data, patients suffering from GBS related to COVID-19 manifested as an acute inflammatory demyelinating polyneuropathy (AIDP). Moreover, we summarized the current findings, which may evidence GBS linking to SARS-CoV-2 infection and COVID-19 vaccination, and discussed the underlying mechanisms whether and how the SARS-CoV-2 virus and COVID-19 vaccination can induce GBS and its variants.
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