Clinical perspectives on the genetics of schizophrenia: A bottom-up orientation

被引：0
作者：
Willem M. A. Verhoeven
Siegfried Tuinier
机构：
[1] Vincent van Gogh Institute for Psychiatry,Department of Clinical Research
[2] Erasmus University Medical Centre,Department of Psychiatry
来源：
Neurotoxicity Research | 2008年 / 14卷
关键词：
Schizophrenia; Genetic syndrome; VCFS; PWS; DISC1;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Phenomenology has been the reference point that investigators have used in their efforts to understand schizophrenia. Although symptoms and signs are crucial for the diagnosis of schizophrenia, there is an ongoing debate since Kraepelin attempted to group symptoms to understand the etiology of schizophrenia. Several operational criteria have been developed to establish the diagnosis of schizophrenia, making it obvious that there are no precise symptomatological boundaries. There is little clear indication which of the systems is valid for genetic and other biological research. Despite the enormous effort to find a linkage between schizophrenia and one or more loci, the results are far from conclusive. Another approach is the search for candidate genes of whichDISCI and 22q11 deletion syndrome are examples.
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页码：141 / 150
页数：9
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