Cross-talk between cancer cells and their neighbors via miRNA in extracellular vesicles: an emerging player in cancer metastasis

被引：0
作者：
Akiko Kogure
Nobuyoshi Kosaka
Takahiro Ochiya
机构：
[1] National Cancer Center Research Institute,Division of Molecular and Cellular Medicine
[2] Tokyo Medical University,Department of Translational Research for Extracellular Vesicles
[3] Tokyo Medical University,Institute of Medical Science
来源：
Journal of Biomedical Science | / 26卷
关键词：
Cancer metastasis; microRNA; Extracellular vesicle; Microenvironment;
D O I：
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摘要：
Cancer metastasis is the major cause of mortality in cancer cases and is responsible for cancer deaths. It is known that cancer cells communicate with surrounding microenvironmental cells, such as fibroblast cells, immune cells, and endothelial cells, to create a cancer microenvironment for their progression. Extracellular vesicles (EVs) are small vesicles that can be secreted by most types of cells and play an important role in cell-to-cell communications via transferring bioactive cargos, including variable RNAs, such as microRNAs (miRNAs), to recipient cells. miRNAs are a class of small noncoding RNAs that posttranscriptionally regulate gene expression. The transfer of them to recipient cells influences the metastatic process of primary tumors. In this review, we summarize the function of miRNAs packaged in EVs in cancer metastasis and discuss the clinical utility of miRNAs in EVs.
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