PDHE1α in DNA damage repair: a critical chromatin acetylation regulator

被引：0
|
作者：
Bingsong Huang
Yuping Chen
Jian Yuan
机构：
[1] Tongji University School of Medicine,Department of Biochemistry and Molecular Biology
[2] Tongji University School of Medicine,Department of Neurosurgery, Shanghai East Hospital
来源：
Genome Instability & Disease | 2023年 / 4卷 / 6期
关键词：
Chromatin acetylation; DNA damage repair; Genome integrity;
D O I：
10.1007/s42764-023-00112-6
中图分类号：
学科分类号：
摘要：
A recent study in Nature Structural and Molecular Biology reveals that chromatin-associated PDHE1α generates acetyl-CoA near DNA double-strand breaks, crucial for chromatin remodeling and DNA repair. PDHE1α recruitment depends on PARP1 and impacts genome stability and cancer therapy resistance. This research sheds light on DNA damage response and chromatin acetylation regulation.
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收藏
页码：349 / 350
页数：1
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