Regulatory T cells in transplantation tolerance

被引：0
作者：
Kathryn J. Wood
Shimon Sakaguchi
机构：
[1] University of Oxford,Nuffield Department of Surgery
[2] John Radcliffe Hospital,Department of Experimental Pathology
[3] Headington,undefined
[4] Institute of Frontier Medical Sciences,undefined
[5] Kyoto University,undefined
来源：
Nature Reviews Immunology | 2003年 / 3卷
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摘要：
Regulation by CD4+CD25+ T cells is one of the mechanisms used in vivo to both induce and maintain transplantation tolerance. Alloantigen-specific regulatory T (TReg) cells can be generated either in vivo or ex vivo. TReg cells are found in the graft, as well as in the peripheral lymphoid tissues, after transplantation. Alloantigen-specific and naturally occurring CD4+CD25+ TReg cells use similar mechanisms to control immune responsiveness in vivo. Alloantigen-specific TReg cells can be augmented by exposure to alloantigen. CD4+CD25+ TReg cells are one form of immunoregulation used to control responsiveness to alloantigens; the relationships between CD4+CD25+ TReg cells and other populations of regulatory cells remain to be clarified.
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页码：199 / 210
页数：11
相关论文
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  • [1] Bach J-F(2003)Regulatory T cells under scrutiny Nature Rev. Immunol. 3 189-198
  • [2] Wells A(2001)The role of peripheral T-cell deletion in transplantation tolerance Philos Trans R Soc Lond B Biol Sci 356 617-623
  • [3] Li X(2001)Alloantigen-induced specific immunological unresponsiveness Philos Trans R Soc Lond B Biol Sci 356 665-680
  • [4] Strom T(1971)Infectious immunological tolerance Immunology 21 903-914
  • [5] Turka L(1975)Suppressor T cells in mice made unresponsive to skin allografts Nature 255 489-491
  • [6] Wood KJ(1986)Suppressor T cells in allogeneic models Transplantation 41 547-555
  • [7] Jones N(2002)Generation of human CD8 T regulatory cells by CD40 ligand-activated plasmacytoid dendritic cells J. Exp. Med. 195 695-704
  • [8] Bushell A(2001)Oral exposure to alloantigen generates intragraft CD8 J. Immunol. 167 107-113
  • [9] Morris PJ(1998) regulatory cells J. Immunol. 161 5193-5202
  • [10] Gershon R(2000)Specific suppression of human CD4 Nature Med. 6 782-789
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