Receptor tyrosine kinases (RTKs) consociate in regulatory clusters in Alzheimer’s disease and type 2 diabetes

被引：0
作者：
Piyali Majumder
Kasturi Roy
Sangram Bagh
Debashis Mukhopadhyay
机构：
[1] Saha Institute of Nuclear Physics,Biophysics and Structural Genomics Division
[2] HBNI,undefined
来源：
Molecular and Cellular Biochemistry | 2019年 / 459卷
关键词：
Alzheimer’s disease; Type 2 diabetes; RTKs; Regulatory clusters;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Alzheimer’s disease (AD) and type 2 diabetes (T2D) share the common hallmark of insulin resistance. It is conjectured that receptor tyrosine kinases (RTKs) play definitive roles in the process. To decipher the signaling overlap behind this phenotypic resemblance, the activity status of RTKs is probed in post-mortem AD and T2D tissues and cell models. Activities of only about one-third changed in a similar fashion, whereas about half of them showed opposite outcomes when exposed to contrasting signals akin to AD and T2D. Interestingly, irrespective of disease type, RTKs with enhanced and compromised activities clustered distinctly, indicating separate levels of regulations. Similar regulatory mechanisms within an activity cluster could be inferred, which have potential to impact future therapeutic developments.
引用
收藏
页码：171 / 182
页数：11
相关论文
共 111 条
[21]  
Li C(2006)GenePattern 2.0 Nat Genet 76 1356-438
[22]  
Mittal K(1999)Learning the parts of objects by non-negative matrix factorization Nature 478 431-115
[23]  
Mani RJ(2012)Palmitate contributes to insulin resistance through downregulation of the Src-mediated phosphorylation of Akt in C2C12 myotubes Biosci Biotechnol Biochem 492 109-73
[24]  
Katare DP(2016)PINK1 alleviates palmitate induced insulin resistance in HepG2 cells by suppressing ROS mediated MAPK pathways Biochem Biophys Res Commun 247 66-1406
[25]  
de Matos AM(2017)PKM2 aggravates palmitate-induced insulin resistance in HepG2 cells via STAT3 pathway Biochem Biophys Res Commun 32 1401-309
[26]  
de Macedo MP(2017)CtBP2 ameliorates palmitate-induced insulin resistance in HepG2 cells through ROS mediated JNK pathway Gen Comp Endocrinol 80 298-E550
[27]  
Rauter AP(2013)Palmitate induces autophagy in pancreatic β-cells via endoplasmic reticulum stress and its downstream JNK pathway Int J Mol Med 294 E540-581
[28]  
Koseoglu MM(2015)Role of hepatocyte S6K1 in palmitic acid-induced endoplasmic reticulum stress, lipotoxicity, insulin resistance and in oleic acid-induced protection Food Chem Toxicol 39 575-9
[29]  
Norambuena A(2008)Differential activation of ER stress and apoptosis in response to chronically elevated free fatty acids in pancreatic beta-cells Am J Physiol Endocrinol Metab 311 1-127
[30]  
Sharlow ER(2007)Discoidin domain receptor 2 impairs insulin-stimulated insulin receptor substrate-1 tyrosine phosphorylation and glucose uptake in 3T3-L1 adipocytes Horm Metab Res Horm Stoffwechselforschung Horm Metab 44 116-101
12345678910