Receptor tyrosine kinases (RTKs) consociate in regulatory clusters in Alzheimer’s disease and type 2 diabetes

被引：0
作者：
Piyali Majumder
Kasturi Roy
Sangram Bagh
Debashis Mukhopadhyay
机构：
[1] Saha Institute of Nuclear Physics,Biophysics and Structural Genomics Division
[2] HBNI,undefined
来源：
Molecular and Cellular Biochemistry | 2019年 / 459卷
关键词：
Alzheimer’s disease; Type 2 diabetes; RTKs; Regulatory clusters;
D O I：
暂无
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学科分类号：
摘要：
Alzheimer’s disease (AD) and type 2 diabetes (T2D) share the common hallmark of insulin resistance. It is conjectured that receptor tyrosine kinases (RTKs) play definitive roles in the process. To decipher the signaling overlap behind this phenotypic resemblance, the activity status of RTKs is probed in post-mortem AD and T2D tissues and cell models. Activities of only about one-third changed in a similar fashion, whereas about half of them showed opposite outcomes when exposed to contrasting signals akin to AD and T2D. Interestingly, irrespective of disease type, RTKs with enhanced and compromised activities clustered distinctly, indicating separate levels of regulations. Similar regulatory mechanisms within an activity cluster could be inferred, which have potential to impact future therapeutic developments.
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页码：171 / 182
页数：11
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