Modeling base excision repair in Escherichia coli bacterial cells

被引：3
作者：
Belov O.V. [1 ]
机构：
[1] Laboratory of Radiation Biology, JINR, Moscow
来源：
Physics of Particles and Nuclei Letters | 2011年 / 8卷 / 2期
关键词：
Nucleus Letter; Base Excision Repair; Gillespie Algorithm; Glycosylase Activity; Base Excision Repair System;
D O I：
10.1134/S1547477111020038
中图分类号：
学科分类号：
摘要：
A model describing the key processes in Escherichia coli bacterial cells during base excision repair is developed. The mechanism is modeled of damaged base elimination involving formamidopyrimidine DNA glycosylase (the Fpg protein), which possesses several types of activities. The modeling of the transitions between DNA states is based on a stochastic approach to the chemical reaction description. © 2011 Pleiades Publishing, Ltd.
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页码：141 / 148
页数：7
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