Marine n-3 Fatty Acids and Gene Expression in Peripheral Blood Mononuclear Cells

被引：13

作者：

Ulven S.M. ^{[1
]}

Myhrstad M.C. ^{[1
]}

Holven K.B. ^{[2
]}

机构：

[1] Department of Health, Nutrition and Management, Faculty of Health Sciences, Oslo and Akershus University College of Applied Sciences (HiOA), P.O. Box 4, St Olavs plass, Oslo

[2] Department of Nutrition, Institute for Basic Medical Sciences, University of Oslo, P.O. Box 1046, Blindern, Oslo

来源：

Current Cardiovascular Risk Reports | 2014年 / 8卷 / 11期

关键词：

Cardiovascular disease; Dietary intervention study; Gene expression; Inflammation; Lipid metabolism; Marine n-3 fatty acids; PBMCs; Peripheral mononuclear cells; Transcriptomics;

D O I：

10.1007/s12170-014-0412-7

中图分类号：

学科分类号：

摘要：

Intake of marine n-3 fatty acids has been shown to have beneficial effects on cardiovascular disease. Gene expression analyses in peripheral blood mononuclear cells (PBMCs) are used to understand the underlying mechanisms of action of marine n-3 fatty acids. The aim of this review was to summarize the effects mediated by marine n-3 fatty acids on gene expression in PBMCs. A systematic literature search was conducted in PubMed in May 2014 and 14 papers were included. Targeted gene expression studies were reported in 9 papers and focused on genes involved in lipid metabolism and inflammation. Whole genome transcriptome analyses were conducted in 5 papers, and processes and pathways related to atherosclerotic plaque formation such as inflammation, oxidative stress response, cell cycle, cell adhesion, and apoptosis were modulated after fish oil supplementation. PBMC gene expression profiling has a potential to clarify further the molecular effects of fish oil consumption on human health. © 2014, The Author(s).

引用

页码：1 / 10

页数：9

共 32 条

[1]

Hu F.B., Bronner L., Willett W.C., Stampfer M.J., Rexrode K.M., Albert C.M., Et al., Fish and omega-3 fatty acid intake and risk of coronary heart disease in women, JAMA, 287, pp. 1815-1821, (2002)

[2]

He K., Song Y., Daviglus M.L., Liu K., Van Horn L., Dyer A.R., Et al., Accumulated evidence on fish consumption and coronary heart disease mortality: a meta-analysis of cohort studies, Circulation, 109, pp. 2705-2711, (2004)

[3]

Burr M.L., Fehily A.M., Gilbert J.F., Rogers S., Holliday R.M., Sweetnam P.M., Et al., Effects of changes in fat, fish, and fibre intakes on death and myocardial reinfarction: diet and reinfarction trial (DART), Lancet, 2, pp. 757-761, (1989)

[4]

Tavazzi L., Maggioni A.P., Marchioli R., Barlera S., Franzosi M.G., Latini R., Et al., Effect of n-3 polyunsaturated fatty acids in patients with chronic heart failure (the GISSI-HF trial): a randomised, double-blind, placebo-controlled trial, Lancet, 372, pp. 1223-1230, (2008)

[5]

Yokoyama M., Origasa H., Matsuzaki M., Matsuzawa Y., Saito Y., Ishikawa Y., Et al., Effects of eicosapentaenoic acid on major coronary events in hypercholesterolaemic patients (JELIS): a randomised open-label, blinded endpoint analysis, Lancet, 369, pp. 1090-1098, (2007)

[6]

Rizos E.C., Ntzani E.E., Bika E., Kostapanos M.S., Elisaf M.S., Association between omega-3 fatty acid supplementation and risk of major cardiovascular disease events: a systematic review and meta-analysis, JAMA, 308, pp. 1024-1033, (2012)

[7]

Wen Y.T., Dai J.H., Gao Q., Effects of Omega-3 fatty acid on major cardiovascular events and mortality in patients with coronary heart disease: a meta-analysis of randomized controlled trials, Nutr Metab Cardiovasc Dis, 24, pp. 470-475, (2014)

[8]

Mozaffarian D., Wu J.H., Omega-3 fatty acids and cardiovascular disease: effects on risk factors, molecular pathways, and clinical events, J Am Coll Cardiol, 58, pp. 2047-2067, (2011)

[9]

Myhrstad M.C., Retterstol K., Telle-Hansen V.H., Ottestad I., Halvorsen B., Holven K.B., Et al., Effect of marine n-3 fatty acids on circulating inflammatory markers in healthy subjects and subjects with cardiovascular risk factors, Inflamm Res, 60, pp. 309-319, (2011)

[10]

Lee C.H., Olson P., Evans R.M., Mini-review: lipid metabolism, metabolic diseases, and peroxisome proliferator-activated receptors, Endocrinology, 144, pp. 2201-2207, (2003)

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