SIRT1 and insulin resistance

SIRT1, a mammalian sirtuin that is known to be involved in the regulation of lifespan, DNA damage response and carcinogenesis, is also likely to influence insulin action. Moreover, increasing evidence suggests that decreased SIRT1 expression or activity might contribute to the pathogenesis of insulin-resistance-related diseases. This review explores the effects of SIRT1 on adiponectin and inflammation, the role of SIRT1 in insulin signaling, and the relationship between SIRT1 and mitochondrial function, which is a potential link with insulin resistance.