The role of autophagy in morphogenesis and stem cell maintenance

被引：0
作者：
Eric Bekoe Offei
Xuesong Yang
Beate Brand-Saberi
机构：
[1] Ruhr University Bochum,Department of Anatomy and Molecular Embryology, Institute of Anatomy
[2] Jinan University,Division of Histology and Embryology, Medical College
[3] University of Ghana,School of Veterinary Medicine
来源：
Histochemistry and Cell Biology | 2018年 / 150卷
关键词：
Autophagy; Atg genes; EMT; Cancer; Morphogenesis; Pluripotent stem cells;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
During embryonic development, cells need to undergo a number of morphological changes that are decisive for the shaping of the embryo’s body, initiating organogenesis and differentiation into functional tissues. These remodeling processes are accompanied by profound changes in the cell membrane, the cytoskeleton, organelles, and extracellular matrix composition. While considerably detailed insight into the role of autophagy in stem cells biology has been gained in the recent years, information regarding the participation of autophagy in morphogenetic processes is only sparse. This review, therefore, focuses on the role of autophagy in cell morphogenesis through its regulatory activity in TGFβ signaling, expression of adhesion molecules and cell cycle modification. It also discusses the role of autophagy in stem cell maintenance which is very fundamental for cell renewal and replacement during development, pathogenesis of certain diseases and development of therapies. We are thus addressing here perspectives for further potentially rewarding research topics.
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页码：721 / 732
页数：11
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