NCAM Mimetic Peptides: Potential Therapeutic Target for Neurological Disorders

被引：0
作者：
Chengyan Chu
Yue Gao
Xiaoyan Lan
Aline Thomas
Shen Li
机构：
[1] Dalian Municipal Central Hospital Affiliated to Dalian Medical University,Department of Neurology
[2] The Johns Hopkins University School of Medicine,Russell H. Morgan Department of Radiology and Radiological Science, Division of MR Research
[3] The Second Hospital of Dalian Medical University,Department of Neurological Rehabilitation
来源：
Neurochemical Research | 2018年 / 43卷
关键词：
Neural cell adhesion molecule; Bioactive peptides; Mimetic peptides; Fibroblast growth factor receptor; Neurological disorders;
D O I：
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中图分类号：
学科分类号：
摘要：
The neural cell adhesion molecule (NCAM) plays a pivotal role in the development and maintenance of the nervous system via homophilic (NCAM–NCAM) and heterophilic (NCAM-other molecules) interactions. Many synthetic peptides have been engineered to mimic these interactions and induce NCAM-downstream signaling pathways. Such NCAM mimetics have displayed neuritogenic and neuroprotective properties, as well as synaptic modulation in vitro and in vivo. Furthermore, they have been used successfully in preclinical studies to treat neurological disorders including stroke, traumatic brain injury and Alzheimer’s disease. This review focuses on recent progress in the development of NCAM mimetic peptides, in particular, on establishing C3, plannexin, and FGL as therapeutic candidates for neurological disorders.
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页码：1714 / 1722
页数：8
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