The SWI/SNF complex and cancer

被引：0
作者：
D Reisman
S Glaros
E A Thompson
机构：
[1] University of Michigan College of Medicine,Department of Internal Medicine
[2] Mayo Clinic Comprehensive Cancer Center,Department of Cancer Biology
来源：
Oncogene | 2009年 / 28卷
关键词：
BRG1; BRM; BAF47; tumor suppressor; chromatin remodeling;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The mammalian SWI/SNF complexes mediate ATP-dependent chromatin remodeling processes that are critical for differentiation and proliferation. Not surprisingly, loss of SWI/SNF function has been associated with malignant transformation, and a substantial body of evidence indicates that several components of the SWI/SNF complexes function as tumor suppressors. This review summarizes the evidence that underlies this conclusion, with particular emphasis upon the two catalytic subunits of the SWI/SNF complexes, BRM, the mammalian ortholog of SWI2/SNF2 in yeast and brahma in Drosophila, and Brahma-related gene-1 (BRG1).
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页码：1653 / 1668
页数：15
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