Polycystin-1 and polycystin-2—it's complicated

被引：0

作者：

Terry J. Watnick

Gregory G. Germino

机构：

[1] Baltimore Polycystic Kidney Disease Research and Clinical Core Center,Division of Nephrology

[2] University of Maryland School of Medicine,undefined

[3] National Institute of Diabetes and Digestive and Kidney Diseases,undefined

[4] National Institutes of Health,undefined

来源：

Nature Reviews Nephrology | 2013年 / 9卷

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摘要：

Mutations in the genes that encode polycystin-1 and polycystin-2 are the principal cause of autosomal dominant polycystic kidney disease. These proteins form a receptor–ion-channel complex and were thought to regulate tubule luminal diameter in a codependent manner. However, new data suggest a more antagonistic relationship between the proteins.

引用

页码：249 / 250

页数：1

共 17 条

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