Structural insights into ligand recognition by the lysophosphatidic acid receptor LPA6

被引：0
作者：
Reiya Taniguchi
Asuka Inoue
Misa Sayama
Akiharu Uwamizu
Keitaro Yamashita
Kunio Hirata
Masahito Yoshida
Yoshiki Tanaka
Hideaki E. Kato
Yoshiko Nakada-Nakura
Yuko Otani
Tomohiro Nishizawa
Takayuki Doi
Tomohiko Ohwada
Ryuichiro Ishitani
Junken Aoki
Osamu Nureki
机构：
[1] Graduate School of Science,Department of Biological Sciences
[2] The University of Tokyo,Department of Systems Biology
[3] Global Research Cluster,Department of Cell Biology
[4] RIKEN,Department of Molecular and Cellular Physiology
[5] Laboratory of Molecular and Cellular Biochemistry,undefined
[6] Graduate School of Pharmaceutical Sciences,undefined
[7] Tohoku University,undefined
[8] Japan Science and Technology Agency (JST),undefined
[9] Precursory Research for Embryonic Science and Technology (PRESTO),undefined
[10] Laboratory of Organic and Medicinal Chemistry,undefined
[11] Graduate School of Pharmaceutical Sciences,undefined
[12] The University of Tokyo,undefined
[13] RIKEN SPring-8 Center,undefined
[14] Laboratory of Heterocyclic Chemistry,undefined
[15] Graduate School of Pharmaceutical Sciences,undefined
[16] Tohoku University,undefined
[17] Graduate School of Biological Sciences,undefined
[18] Nara Institute of Science and Technology,undefined
[19] Graduate School of Medicine,undefined
[20] Kyoto University,undefined
[21] Japan Agency for Medical Research and Development,undefined
[22] Core Research for Evolutional Science and Technology (AMED-CREST),undefined
[23] Stanford University School of Medicine,undefined
来源：
Nature | 2017年 / 548卷
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摘要：
Determination of the crystal structure of the zebrafish LPA6 receptor shows that the lipid ligand binds to an unusual ligand-binding pocket in the receptor that is laterally accessible through the membrane.
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页码：356 / 360
页数：4
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