Generation of CD8+ Cytotoxic T Lymphocytes Against Breast Cancer Cells by Stimulation with Mammaglobin-A-Pulsed Dendritic Cells

被引：0
作者：
Partha P. Manna
Andrés Jaramillo
Kanchana Majumder
Lacey G. Campbell
Timothy P. Fleming
Jill R. Dietz
John F. Dipersio
T. Mohanakumar
机构：
[1] Washington University School of Medicine,Department of Surgery
[2] Washington University School of Medicine,Department of Internal Medicine
[3] Washington University School of Medicine,Department of Pathology and Immunology
来源：
Breast Cancer Research and Treatment | 2003年 / 79卷
关键词：
CD8+ T lymphocytes; cytotoxic activity; dendritic cells; mammaglobin-A; tumor-specific antigen;
D O I：
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学科分类号：
摘要：
Mammaglobin-A is exclusively expressed by breast cancer cells. Thus, mammaglobin-A-specific T cell immune responses may be useful for the design of new breast cancer-specific immunotherapies. We show herein that CD8+ T cells generated against recombinant mammaglobin-A-pulsed dendritic cells display a marked cytotoxic activity against mammaglobin-A-positive breast cancer cell lines. This study indicates the immunotherapeutic potential of this novel antigen for the treatment of breast cancer.
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页码：133 / 136
页数：3
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