Modification of the Pictet–Spengler reaction in the synthesis of fused 2,3-benzodiazocines

被引：0
作者：
A. S. Tolkunov
V. N. Baumer
G. V. Palamarchuk
O. V. Shishkin
A.V. Mazepa
S. V. Tolkunov
S. L. Bogza
机构：
[1] National Academy of Sciences of Ukraine,L. M. Litvinenko Institute of Physical
[2] Institute for Single Crystals of the National Academy of Sciences of Ukraine,Organic Chemistry and Coal Chemistry
[3] V. N. Karazin Kharkiv National University,Research Branch for the Chemistry of Functional Materials
[4] National Academy of Sciences of Ukraine,A. V. Bogatsky Physico
来源：
Chemistry of Heterocyclic Compounds | 2011年 / 47卷
关键词：
3-amino-2-[2-(3,4-dimethoxyphenyl)ethyl]quinazolin-4(3; )-one; fused diazocines; hydrochloric acid; tetrahydroquinazolino[3,2-; ][2,3]benzodiazocin-15-ones; trifluoroacetic acid; cyclization; Pictet–Spengler reaction;
D O I：
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中图分类号：
学科分类号：
摘要：
A new strategy for the synthesis of the eight-membered heterocyclic skeleton of tetrahydro-quinazolino[3,2-c][2,3]benzodiazocin-15-ones, based on the Pictet–Spengler reaction of 3-amino-2-[2-(3,4-dimethoxyphenyl)ethyl]quinazolin-4(3H)-one with carbonyl compounds in acidic media, is proposed.
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页码：1006 / 1013
页数：7
相关论文
共 32 条
  • [1] Horvath EJ(2000)undefined Prog. Neurobiol. 60 309-undefined
  • [2] Horvath K(1989)undefined Tetrahedron 45 2875-undefined
  • [3] Hamori T(1960)undefined J. Org. Chem. 25 1509-undefined
  • [4] Fekete MIK(1976)undefined J. Org. Chem. 41 3229-undefined
  • [5] Solyom S(1991)undefined J. Org. Chem. 56 3457-undefined
  • [6] Palkovits M(2010)undefined Khim. Geterotsikl. Soedin. 46 745-undefined
  • [7] Atkinson RS(2010)undefined Khim. Geterotsikl. Soedin. 46 882-undefined
  • [8] Grimshire MJ(2007)undefined Khim. Geterotsikl. Soedin. 43 1740-undefined
  • [9] Kelly BJ(1989)undefined Usp. Khim. 58 713-undefined
  • [10] Allinger NL(2008)undefined Acta Crystallogr. A64 112-undefined
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