CAG polymorphism of the androgen receptor gene in azoospermic and oligozoospermic men from Ukraine

被引:0
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作者
O. A. Fesai
S. A. Kravchenko
M. Ya. Tyrkus
G. V. Makuh
V. M. Zinchenko
G. V. Strelko
L. A. Livshits
机构
[1] Ukraine National Academy of Sciences,Institute of Molecular Biology and Genetics
[2] Ukraine Academy of Medical Sciences,Institute of Hereditary Pathology
[3] ISIDA-IVF Clinic,undefined
[4] Viktoriya Clinic,undefined
来源
Cytology and Genetics | 2009年 / 43卷
关键词
Androgen Receptor; Azoospermia; Androgen Receptor Gene; Polyglutamine Tract; Androgen Receptor Mrna;
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学科分类号
摘要
An analysis of the number of CAG repeats in exon 1 of the gene was conducted in a group of 228 infertile males with azoospermia (n = 68) and oligozoospermia (n = 160), and in a control group (124 proven fathers) by means of polymerase chain reaction with subsequent fragment analysis on an ALF-Express automated fluorescent analyzer. Allele frequency with the number of CAG repeats ≤ 18 was found to be significantly higher (P < 0.01) in the group of patients with azoospermia (17.7%) as compared to the control group (2.4%), and in the group of patients with oligozoospermia (12.5%) as compared to the control group (2.4%). Allele frequency with the number of CAG repeats ≥ 28 was shown to be significantly higher (P < 0.01) in patients with oligozoospermia (12.5%) as compared to the control group (2.4%). Our data suggest an association between the number of CAG repeats and impaired spermatogenesis in azoospermic and oligozoospermic males.
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页码:401 / 405
页数:4
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