TGFBR1*6A/9A polymorphism and cancer risk: a meta-analysis of 13,662 cases and 14,147 controls

被引：0
作者：
Ru-Yan Liao
Chen Mao
Li-Xin Qiu
Hong Ding
Qing Chen
Hai-Feng Pan
机构：
[1] Southern Medical University,Department of Epidemiology, School of Public Health and Tropical Medicine
[2] Nanjing Medical University,Cancer Center, Nanjing Drum Tower Hospital
[3] Longgang Center for Disease Control and Prevention of Shenzhen,Department of Epidemiology and Biostatistics, School of Public Health
[4] Anhui Medical University,undefined
来源：
Molecular Biology Reports | 2010年 / 37卷
关键词：
Polymorphism; Cancer; Susceptibility; Meta-analysis;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Published data on the association between TGFBR1*6A/9A polymorphism and cancer risk are inconclusive. To derive a more precise estimation of the relationship, a meta-analysis was performed. A total of 32 studies including 13,662 cases and 14,147 controls were involved in this meta-analysis. Overall, significantly elevated cancer risks were associated with TGFBR1*6A in all genetic models (for allelic effect: OR = 1.11; 95% CI = 1.03–1.21; for 6A/6A vs. 9A/9A: OR = 1.30; 95% CI = 1.01–1.69; for 9A/6A vs. 9A/9A: OR = 1.08; 95% CI = 1.01–1.15; for dominant model: OR = 1.08; 95% CI = 1.02–1.15; for recessive model: OR = 1.29; 95% CI = 1.00–1.68). In the subgroup analysis by cancer types, significant associations were found in breast cancer (for allelic effect: OR = 1.16; 95% CI = 1.01–1.34) and ovarian cancer (for allelic effect: OR = 1.24; 95% CI = 1.00–1.54; for 6A/6A vs. 9A/9A: OR = 2.34; 95% CI = 1.03–5.33). However, no significant associations were found in colorectal cancer, bladder cancer, prostate cancer and lung cancer for all genetic models. In summary, this meta-analysis suggests that the TGFBR1*6A/9A polymorphism is associated with cancer susceptibility, increasing the risk of breast and ovarian cancer.
引用
收藏
页码：3227 / 3232
页数：5
相关论文
共 169 条
  • [1] Soerjomataram I(2008)An overview of prognostic factors for long-term survivors of breast cancer Breast Cancer Res Treat 107 309-330
  • [2] Louwman MW(2008)Recent trends of cancer in Europe: a combined approach of incidence, survival and mortality for 17 cancer sites since the 1990s Eur J Cancer 44 1345-1389
  • [3] Ribot JG(2000)Environmental and heritable factors in the causation of cancer—analyses of cohorts of twins from Sweden, Denmark, and Finland N Engl J Med 343 78-85
  • [4] Roukema JA(1993)Cloning of a type I TGF-β receptor and its effect on TGF-β binding to the type II receptor Science 260 1344-1348
  • [5] Coebergh JW(1999)TbetaR-I (6A) is a candidate tumor susceptibility allele Cancer Res 59 5678-5682
  • [6] Karim-Kos HE(1999)Structural alterations of transforming growth factor-beta receptor genes in human cervical carcinoma Int J Cancer 82 43-51
  • [7] De Vries E(2001)The chromosome 9q genes TGFBR1, TSC1, and ZNF189 are rarely mutated in bladder cancer J Pathol 194 76-80
  • [8] Soerjomataram I(2001)TbetaR-I(6A) polymorphism is not a tumor susceptibility allele in Macedonian colorectal cancer patients. Correspondence re: B. Pasche et al. Type I TbetaR-I (6A) Is a candidate tumor susceptibility allele. Cancer Res., 58:2727–2732, 1998 Cancer Res 61 8351-8352
  • [9] Lemmens V(2001)Uncommon TGFBRI allele is not associated with increased susceptibility to colon cancer Genes Chromosom Cancer 32 381-383
  • [10] Siesling S(2002)Transforming growth factor beta receptor 1 polyalanine polymorphism and exon 5 mutation analysis in breast and ovarian cancer Cancer Epidemiol Biomarkers Prev 11 211-214
12345678910