'Hot flush', an unpleasant symptom accompanying antiandrogen therapy of prostatic cancer and its treatment by cyproterone acetate

被引：16

作者：

Cervenakov I. ^{[1
]}

Kopecny M. ^{[1
]}

Jancar M. ^{[1
]}

Chovan D. ^{[1
]}

Mal'a M. ^{[1
]}

机构：

[1] Department of Urology and Andrology, University Hospital of Bratislava

来源：

International Urology and Nephrology | 2000年 / 32卷 / 1期

关键词：

'Hot flush'; Androgens; Carcinoma of the prostate; Centre of termoregulation; Hypophysis catecholamines; Hypothalamus;

D O I：

10.1023/A:1007164319067

中图分类号：

学科分类号：

摘要：

From 1995 to 1997 the authors have assessed 31 patients with histologically verified advanced carcinoma of the prostate (CaP) and the ensuing symptom of 'hot flush'. Patients underwent transurethral resection of the prostate (TURP), bilateral orchiectomy (OE) and combined androgen blockade (CAB) by the administration of non-steroid antiadrogens. The authors present the mechanism of the genesis of the 'hot flush' symptom as well as its subjective manifestations, methods of laboratory monitoring as well as their experience with the treatment of this symptom. 50 mg tablets cyproterone acetate administered twice daily or Androcur depot 300 mg i.m. inj. once in 14 days were the main factors in the treatment of 'hot flushes' which reduced subjective difficulties in 80.6% of the patients studied.

引用

页码：77 / 79

页数：2

共 17 条

[1]

Kliment J., Prostate cancer, an introduction, Klin Onko SK, 9, (1996)

[2]

Kliment J., Hormonal treatment of advanced prostate cancer, Klin Onko SK, 9, (1996)

[3]

Kliment J., Hornak M., Carcinoma of the prostate, Vydavatel'stvo Osveta, (1999)

[4]

Huggins C., Stevens R.E., Hodges C.V., Studies on prostatic cancer II. The effects of castration on advanced carcinoma of prostate gland, Arch Surg, 43, (1941)

[5]

Walsh P.C., Physiologic basis for hormonal therapy in carcinoma of the prostate, Urol Clin N Am, 2, (1975)

[6]

Debruyne F.N.M., Dijukman G.A., Advances and trends in hormonal therapy for advanced prostate cancer, Eur Urol, 28, (1995)

[7]

Tomaskin R., Kliment J., Elias B., Appearance, origin mechanism and therapy of 'hot flushes' after bilateral orchiectomy for prostate cancer, Prostata SK, 1, (1997)

[8]

Smith J.A., A prospective comparison of treatments for symptomatic hot flushes following endocrine therapy for carcinoma of prostate, J Urol, 125, (1994)

[9]

Labrie F., Intracrinology its impact on prostate cancer, Curr Opinion Urol, 3, (1993)

[10]

Buchholz N.P., Mattarelli G., Hot flushes after orchiectomy in treatment of prostate cancer-A serious side effect, Z-Gerontol, 27, (1994)

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