A genome-wide survey and functional brain imaging study identify CTNNBL1 as a memory-related gene

被引：0
作者：
A Papassotiropoulos
E Stefanova
C Vogler
L Gschwind
S Ackermann
K Spalek
B Rasch
A Heck
A Aerni
E Hanser
P Demougin
K-D Huynh
R Luechinger
M Klarhöfer
I Novakovic
V Kostic
P Boesiger
K Scheffler
D J-F de Quervain
机构：
[1] University of Basel,Division of Molecular Neuroscience, Department of Psychology
[2] University of Basel,Department Biozentrum
[3] Psychiatric University Clinics,Division of Cognitive Neuroscience, Department of Psychology
[4] Life Sciences Training Facility,Division of Radiological Physics
[5] University of Basel,MRC Department
[6] Institute of Neurology,Department of Neuroimaging and MR
[7] CCS,Physics
[8] School of Medicine,undefined
[9] University of Belgrade,undefined
[10] University of Basel,undefined
[11] Institute for Biomedical Engineering,undefined
[12] University and ETH Zürich,undefined
[13] University Hospital Basel,undefined
[14] University of Basel,undefined
[15] Institute of Biology,undefined
[16] School of Medicine,undefined
[17] University of Belgrade,undefined
[18] MPI for Biological Cybernetics,undefined
[19] University of Tübingen,undefined
来源：
Molecular Psychiatry | 2013年 / 18卷
关键词：
beta-catenin-like; fMRI; GWAS; memory;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Unbiased genome-wide screens combined with imaging data on brain function may identify novel molecular pathways related to human cognition. Here we performed a dense genome-wide screen to identify episodic memory-related gene variants. A genomic locus encoding the brain-expressed beta-catenin-like protein 1 (CTNNBL1) was significantly (P=7 × 10−8) associated with verbal memory performance in a cognitively healthy cohort from Switzerland (n=1073) and was replicated in a second cohort from Serbia (n=524; P=0.003). Gene expression studies showed CTNNBL1 genotype-dependent differences in beta-catenin-like protein 1 mRNA levels in the human cortex. Functional magnetic resonance imaging in 322 subjects detected CTNNBL1 genotype-dependent differences in memory-related brain activations. Converging evidence from independent experiments and different methodological approaches suggests a role for CTNNBL1 in human memory.
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页码：255 / 263
页数：8
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