Mesenchymal stem cells as a double-edged sword in tumor growth: focusing on MSC-derived cytokines

被引：0
作者：
Wenqing Liang
Xiaozhen Chen
Songou Zhang
Jian Fang
Meikai Chen
Yifan Xu
Xuerong Chen
机构：
[1] Zhoushan Hospital of Traditional Chinese Medicine Affiliated to Zhejiang Chinese Medical University,Department of Orthopaedics
[2] Shaoxing University,College of Medicine
[3] The First Affiliated Hospital of Shaoxing University,Department of Orthopaedics, Shaoxing People’s Hospital
来源：
Cellular & Molecular Biology Letters | 2021年 / 26卷
关键词：
Angiogenesis; Cancer-associated fibroblasts; Immunosuppression; Metastasis; Mesenchymal stem cells;
D O I：
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摘要：
Mesenchymal stem cells (MSCs) show homing capacity towards tumor sites. Numerous reports indicate that they are involved in multiple tumor-promoting processes through several mechanisms, including immunosuppression; stimulation of angiogenesis; transition to cancer-associated fibroblasts; inhibition of cancer cell apoptosis; induction of epithelial–mesenchymal transition (EMT); and increase metastasis and chemoresistance. However, other studies have shown that MSCs suppress tumor growth by suppressing angiogenesis, incrementing inflammatory infiltration, apoptosis and cell cycle arrest, and inhibiting the AKT and Wnt signaling pathways. In this review, we discuss the supportive and suppressive impacts of MSCs on tumor progression and metastasis. We also discuss MSC-based therapeutic strategies for cancer based on their potential for homing to tumor sites.
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