Genetically mimicked effects of ASGR1 inhibitors on all-cause mortality and health outcomes: a drug-target Mendelian randomization study and a phenome-wide association study

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作者
Guoyi Yang
C. Mary Schooling
机构
[1] The University of Hong Kong,School of Public Health, Li Ka Shing Faculty of Medicine
[2] City University of New York,Graduate School of Public Health and Health Policy
来源
BMC Medicine | / 21卷
关键词
All-cause mortality; ASGR1 inhibitors; Mendelian randomization; Phenome-wide association study; Cardiovascular disease;
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[1]  
Ashwell G(1982)Carbohydrate-specific receptors of the liver Annu Rev Biochem 51 531-554
[2]  
Harford J(2016)Variant ASGR1 associated with a reduced risk of coronary artery disease N Engl J Med 374 2131-2141
[3]  
Nioi P(2020)Common gene variants in ASGR1 gene locus associate with reduced cardiovascular risk in absence of pleiotropic effects Atherosclerosis 306 15-21
[4]  
Sigurdsson A(2022)Inhibition of ASGR1 decreases lipid levels by promoting cholesterol excretion Nature 608 413-420
[5]  
Thorleifsson G(2022)Targeting ASGR1 to lower cholesterol Nat Metab 4 967-969
[6]  
Helgason H(2021)Deficiency of ASGR1 in pigs recapitulates reduced risk factor for cardiovascular disease in humans PLoS Genet 17 e1009891-2128
[7]  
Agustsdottir AB(2014)The ABCG5/8 cholesterol transporter and myocardial infarction versus gallstone disease J Am Coll Cardiol 63 2121-1163
[8]  
Norddahl GL(2008)Mendelian randomization: using genes as instruments for making causal inferences in epidemiology Stat Med 27 1133-361
[9]  
Helgadottir A(2015)HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight: evidence from genetic analysis and randomised trials Lancet 385 351-240
[10]  
Magnusdottir A(2022)Obesity partially mediates the diabetogenic effect of lowering LDL cholesterol Diabetes Care 45 232-699