Subcellular Localization of Fragile X Mental Retardation Protein with the I304N Mutation in the RNA-Binding Domain in Cultured Hippocampal Neurons

被引：0

作者：

Maija Castrén

Annakaisa Haapasalo

Ben A. Oostra

Eero Castrén

机构：

[1] University of Kuopio,A.I. Virtanen Institute

[2] University Hospital of Kuopio,Department of Pediatrics, University and

[3] Erasmus University,Department of Clinical Genetics

[4] University of Kuopio,Department of Psychiatry

来源：

Cellular and Molecular Neurobiology | 2001年 / 21卷

关键词：

fragile X syndrome; hippocampus; neurons; FMRP; synaptophysin; synapses;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

1. Fragile X syndrome, the most common form of inherited mental retardation,iscaused by the lack or dysfunction of fragile X mental retardationprotein (FMRP). The I304N mutation in the RNA-binding domain of FMRP results in an exceptionally severe form of mental retardation.

引用

页码：29 / 38

页数：9

共 39 条

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Castrén, M
Haapasalo, A
Oostra, BA
Castrén, E
CELLULAR AND MOLECULAR NEUROBIOLOGY, 2001, 21 (01) : 29 - 38
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Khandjian, EW
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Athar, Youssi M.
Joseph, Simpson
JOURNAL OF MOLECULAR BIOLOGY, 2020, 432 (13) : 3851 - 3868
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Zang, Julie B.
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PLOS GENETICS, 2009, 5 (12):
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Joseph, Simpson
BIOCHIMIE, 2015, 114 : 147 - 154
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Biophysical Reviews, 2020, 12 (4) : 903 - 916
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Castrén, M
Haapasalo, AK
Oostra, BE
Castrén, E
EUROPEAN JOURNAL OF NEUROSCIENCE, 1998, 10 : 429 - 429
[8] The nuclear MicroSpherule protein 58 is a novel RNA-binding protein that interacts with fragile X mental retardation protein in polyribosomal mRNPs from neurons
Davidovic, L
Bechara, E
Gravel, M
Jaglin, XH
Tremblay, S
Sik, A
Bardoni, B
Khandjian, EW
HUMAN MOLECULAR GENETICS, 2006, 15 (09) : 1525 - 1538
[9] A novel RNA-binding nuclear protein that interacts with the fragile X mental retardation (FMR1) protein
Bardoni, B
Schenck, A
Mandel, JL
HUMAN MOLECULAR GENETICS, 1999, 8 (13) : 2557 - 2566
[10] The nuclear isoforms of the Fragile X mental retardation RNA-binding protein associate with genomic DNA bridges
Ledoux, N.
Gauthier-Naud, W.
Lavoie, O.
Hussein, S.
Adjibade, P.
Mazroui, R.
MOLECULAR BIOLOGY OF THE CELL, 2023, 34 (05)

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