Synthesis and biological evaluation of some Schiff bases of 4-amino-5-(4-methylsulfonyl)benzyl-2,4-dihydro-3H-[1,2,4]-triazole-3-thione

被引：0
作者：
V. Sumangala
Boja Poojary
N. Chidananda
T. Arulmoli
Shalini Shenoy
机构：
[1] Mangalore University,Department of Chemistry
[2] SeQuent Scientific Limited,Department of Microbiology
[3] KMC,undefined
来源：
Medicinal Chemistry Research | 2013年 / 22卷
关键词：
Triazoles; Schiff base; Cytotoxicity; Antimicrobial activity;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The basic nucleus 4-amino-5-[4-(methylsulfonyl)benzyl]-2,4-dihydro-3H-[1,2,4]-triazole-3-thione was prepared by cyclisation of potassium dithiocarbazinate with hydrazine hydrate using ethanol as solvent under reflux condition. The compound which has been synthesized successfully was subjected to addition reaction with different aldehydes to synthesize Schiff bases. The compounds were confirmed by spectroscopic methods (IR, NMR, and Mass). In order to ascertain the pharmaceutical application, the selective pharmacological screening of the derivatives was carried out according to the standard procedures. The compounds were screened for their cytotoxic activity and antimicrobial activity.
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页码：2921 / 2928
页数：7
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