SAR comparative studies on pyrimido[4,5-b][1,4] benzothiazine derivatives as 15-lipoxygenase inhibitors, using ab initio calculations

被引：0
作者：
Mehdi Bakavoli
Hamid Sadeghian
Zahra Tabatabaei
Elham Rezaei
Mohammad Rahimizadeh
Mohsen Nikpour
机构：
[1] Ferdowsi University of Mashhad,Department of Chemistry, Faculty of Sciences
[2] Islamic Azad University,Department of Chemistry, School of Sciences
[3] Islamic Azad University,Department of Chemistry, School of Sciences
来源：
Journal of Molecular Modeling | 2008年 / 14卷
关键词：
5-Bromo-2,4-dichloropyrimidine; Docking; SLO; QSAR;
D O I：
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中图分类号：
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摘要：
The enzyme inhibitory activity of a new group of 2-substituted pyrimido[4,5-b][1,4]benzothiazines on soybean 15-lipoxygenase (15-LO) was evaluated and compared with those of their 4-methyl analogs using ab initio calculations. The results of these studies showed that the lack of 4-methyl substituent in the pyrimido[4,5-b][1,4] benzothiazine molecules greatly reduces their 15-LO inhibitory activities.
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[1]  
Brash AR(1999)undefined J Biol Chem 274 23679-23682
[2]  
Kuhn H(1999)undefined FEBS Lett 449 7-11
[3]  
Thiele BJ(1993)undefined Ann Pharmacother 27 898-903
[4]  
Larsen JS(2002)undefined Biol Chem 383 365-374
[5]  
Acosta EP(2002)undefined Curr Urol Rep 3 207-214
[6]  
Schewe T(2000)undefined Carcinogenesis 21 1777-1787
[7]  
Kelavkar U(2002)undefined Am J Respir Cell Mol Biol 27 666-677
[8]  
Glasgow W(2004)undefined Trends Cardiovasc Med 14 191-195
[9]  
Eling TE(2000)undefined Arteriosler Thromb Vasc Biol 20 2100-2105
[10]  
Kelavkar UP(1996)undefined Cell Phys 167 467-487
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