Expression of the immune regulation antigen CD70 in osteosarcoma

被引：0
|
作者：
Jens HW Pahl
Susy J Santos
Marieke L Kuijjer
Gerharda H Boerman
Laurens GL Sand
Karoly Szuhai
Annemarie Cleton-Jansen
R Maarten Egeler
Judith VMG Boveé
Marco W Schilham
Arjan C Lankester
机构：
[1] Leiden University Medical Center,Department of Pediatrics
[2] Leiden University Medical Center,Department of Pathology
[3] Leiden University Medical Center,Department of Molecular Cell Biology
[4] Innate Immunity Group,Division of Hematology/Oncology
[5] German Cancer Research Center,undefined
[6] Hospital for Sick Children/University of Toronto,undefined
来源：
Cancer Cell International | / 15卷
关键词：
CD70; Osteosarcoma; Immunotherapy; CD27;
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学科分类号：
摘要：
Osteosarcoma is the most frequent bone cancer in children and young adults. The outcome of patients with advanced disease is dismal. Exploitation of tumor-immune cell interactions may provide novel therapeutic approaches. CD70-CD27 interactions are important for the regulation of adaptive immunity. CD70 expression has been reported in some solid cancers and implicated in tumor escape from immunosurveillance. In this study, expression of CD70 and CD27 was analyzed in osteosarcoma cell lines and tumor specimens.
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