Decoding the non-coding RNAs in Alzheimer’s disease

被引：0
作者：
Nicole Schonrock
Jürgen Götz
机构：
[1] Victor Chang Cardiac Research Institute (VCCRI),St. Vincent’s Clinical School, Faculty of Medicine
[2] University of New South Wales,Centre for Ageing Dementia Research, Queensland Brain Institute
[3] The University of Queensland,undefined
来源：
Cellular and Molecular Life Sciences | 2012年 / 69卷
关键词：
Non-coding RNAs; MicroRNAs; Alzheimer’s disease (AD); Amyloid-beta; APP (amyloid precursor protein); Tau; Frontotemporal dementia; FTLD; Gene regulatory networks;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Non-coding RNAs (ncRNAs) are integral components of biological networks with fundamental roles in regulating gene expression. They can integrate sequence information from the DNA code, epigenetic regulation and functions of multimeric protein complexes to potentially determine the epigenetic status and transcriptional network in any given cell. Humans potentially contain more ncRNAs than any other species, especially in the brain, where they may well play a significant role in human development and cognitive ability. This review discusses their emerging role in Alzheimer’s disease (AD), a human pathological condition characterized by the progressive impairment of cognitive functions. We discuss the complexity of the ncRNA world and how this is reflected in the regulation of the amyloid precursor protein and Tau, two proteins with central functions in AD. By understanding this intricate regulatory network, there is hope for a better understanding of disease mechanisms and ultimately developing diagnostic and therapeutic tools.
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页码：3543 / 3559
页数：16
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