Multiomic approaches to stroke: the beginning of a journey

被引:0
作者
Stéphanie Debette
Daniel I. Chasman
机构
[1] University of Bordeaux,Division of Preventive Medicine
[2] INSERM U1219,undefined
[3] Bordeaux Population Health (BPH) Research Center,undefined
[4] Bordeaux University Hospital,undefined
[5] Department of Neurology,undefined
[6] Institute for Neurodegenerative Diseases,undefined
[7] Brigham and Women’s Hospital,undefined
[8] Harvard Medical School,undefined
来源
Nature Reviews Neurology | 2024年 / 20卷
关键词
D O I
暂无
中图分类号
学科分类号
摘要
Using integrative multiomics, a new study has shed light on the aetiology of ischaemic stroke. By probing the mechanisms underlying stroke, such approaches could aid the development of therapies and improve risk prediction and stratification, with the ultimate aim of developing personalized preventive and therapeutic strategies.
引用
收藏
页码:65 / 66
页数:1
相关论文
共 15 条
[1]  
Jung J(2023)Novel insight into the etiology of ischemic stroke gained by integrative multiome-wide association study Hum. Mol. Genet. 22 864-264
[2]  
Lu Z(2023)Genetic support for FDA-approved drugs over the past decade Nat. Rev. Drug Discov. 16 247-123
[3]  
de Smith A(2020)Multilevel omics for the discovery of biomarkers and therapeutic targets for stroke Nat. Rev. Neurol. 611 115-304
[4]  
Mancuso N(2022)Stroke genetics informs drug discovery and risk prediction across ancestries Nature 13 360-1276
[5]  
Rusina PV(2019)TMEM16A inhibition preserves blood-brain barrier integrity after ischemic stroke Front. Cell. Neurosci. 30 294-714
[6]  
Montaner J(2021)Integration of genetically regulated gene expression and pharmacological library provides therapeutic drug candidates Hum. Mol. Genet. 119 1267-undefined
[7]  
Mishra A(2022)Stroke-associated intergenic variants modulate a human FOXF2 transcriptional enhancer Proc. Natl Acad. Sci. USA 10 693-undefined
[8]  
Liu PY(2014)Integrating functional data to prioritize causal variants in statistical fine-mapping studies PLoS Genet. 55 undefined-undefined
[9]  
Konuma T(2023)Leveraging polygenic enrichments of gene features to predict genes underlying complex traits and diseases Nat. Genet. 186 undefined-undefined
[10]  
Ogawa K(2023)Hallmarks of neurodegenerative diseases Cell undefined undefined-undefined