NMR assignments of the macro domain from Middle East respiratory syndrome coronavirus (MERS-CoV)

被引：0
作者：
Yi-Ping Huang
Chao-Cheng Cho
Chi-Fon Chang
Chun-Hua Hsu
机构：
[1] Academia Sinica,Genomics Research Center
[2] National Taiwan University and Academia Sinica,Genome and Systems Biology Degree Program
[3] National Taiwan University,Department of Agricultural Chemistry
[4] National Taiwan University,Center for Systems Biology
来源：
Biomolecular NMR Assignments | 2016年 / 10卷
关键词：
Viral macro domain; MERS-CoV; ADP-ribose binding module; NMR spectroscopy;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The newly emerging human pathogen, Middle East respiratory syndrome coronavirus (MERS-CoV), contains a macro domain in the highly conserved N-terminal region of non-structural protein 3. Intense research has shown that macro domains bind ADP-ribose and other derivatives, but it still remains intangible about their exact function. In this study we report the preliminary structural analysis through solution NMR spectroscopy of the MERS-CoV macro domain. The near complete NMR assignments of MERS-CoV macro domain provide the basis for subsequent structural and biochemical investigation in the context of protein function.
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页码：245 / 248
页数：3
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