Gated myocardial perfusion SPECT underestimates left ventricular volumes and shows high variability compared to cardiac magnetic resonance imaging -- a comparison of four different commercial automated software packages

被引：25

作者：

Hedeer F. ^{[1
]}

Palmer J. ^{[2
]}

Arheden H. ^{[1
]}

Ugander M. ^{[1
]}

机构：

[1] Department of Clinical Physiology, Lund University, Skåne University Hospital, Lund

[2] Department of Radiation Physics, Lund University, Skåne University Hospital, Lund

来源：

BMC Medical Imaging | / 10卷 / 1期

关键词：

Magnetic Resonance Imaging; Left Ventricular Ejection Fraction; Left Ventricular Volume; Myocardial Perfusion Single; Myocardial Perfusion Single Image;

D O I：

10.1186/1471-2342-10-10

中图分类号：

学科分类号：

摘要：

Background: We sought to compare quantification of left ventricular volumes and ejection fraction by different gated myocardial perfusion SPECT (MPS) programs with each other and to magnetic resonance (MR) imaging.Methods: N = 100 patients with known or suspected coronary artery disease were examined at rest with 99 mTc-tetrofosmin gated MPS and cardiac MR imaging. Left ventricular end-diastolic volume (EDV), end-systolic volume (ESV), stroke volume (SV) and ejection fraction (EF) were obtained by analysing gated MPS data with four different programs: Quantitative Gated SPECT (QGS), GE MyoMetrix, Emory Cardiac Toolbox (ECTb) and Exini heart.Results: All programs showed a mean bias compared to MR imaging of approximately -30% for EDV (-22 to -34%, p < 0.001 for all), ESV (-12 to -37%, p < 0.001 for ECTb, p < 0.05 for Exini, p = ns for QGS and MyoMetrix) and SV (-21 to -41%, p < 0.001 for all). Mean bias ± 2 SD for EF (% of EF) was -9 ± 27% (p < 0.01), 6 ± 29% (p = ns), 15 ± 27% (p < 0.001) and 0 ± 28% (p = ns) for QGS, ECTb, MyoMetrix, and Exini, respectively.Conclusions: Gated MPS, systematically underestimates left ventricular volumes by approximately 30% and shows a high variability, especially for ESV. For EF, accuracy was better, with a mean bias between -15 and 6% of EF. It may be of value to take this into consideration when determining absolute values of LV volumes and EF in a clinical setting. © 2010 Hedeer et al; licensee BioMed Central Ltd.

引用

共 22 条

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