Prevalence of TPMT, ITPA and NUDT 15 genetic polymorphisms and their relation to 6MP toxicity in north Indian children with acute lymphoblastic leukemia

[1] Wall AM(2003)Pharmacogenomic effects on therapy for acute lymphoblastic leukemia in children Pharmacogenomics J 3 128-2301

[2] Rubnitz JE(2001)Preponderance of thiopurine S-methyltransferase deficiency and heterozygosity among patients intolerant to mercaptopurine or azathioprine J Clin Oncol 19 2293-3995

[3] Evans WE(2015)Inherited genetic variation in childhood acute lymphoblastic leukemia Blood 125 3988-2008

[4] Moriyama T(1999)Mercaptopurine therapy intolerance and heterozygosity at the thiopurine S-methyltransferase gene locus J Natl Cancer Inst 91 2001-325

[5] Relling MV(2013)Clinical pharmacogenetics implementation consortium guidelines for thiopurine methyltransferase genotype and thiopurine dosing: 2013 update Clin Pharmacol Ther 93 324-195

[6] Yang JJ(2002)Molecular analysis of thiopurine S-methyltransferase alleles in South-east Asian populations Pharmacogenetics 12 191-70

[7] Relling MV(2004)Thiopurine S-methyltransferase genetic polymorphism in the Thai population Br J Clin Pharmacol 58 66-564

[8] Relling MV(2012)The activity of the inosine triphosphate pyrophosphatase affects toxicity of 6-mercaptopurine during maintenance therapy for acute lymphoblastic leukemia in Japanese children Leuk Res 36 560-1020

[9] Chang JG(2014)A common missense variant in NUDT15 confers susceptibility to thiopurine-induced leukopenia Nat Genet 46 1017-e26

[10] Srimartpirom S(2016)NUDT15 c.415C > T increases risk of 6-mercaptopurine induced myelosuppression during maintenance therapy in children with acute lymphoblastic leukemia Haematologica 101 e24-614

[1] Wall AM(2003)Pharmacogenomic effects on therapy for acute lymphoblastic leukemia in children Pharmacogenomics J 3 128-2301

[2] Rubnitz JE(2001)Preponderance of thiopurine S-methyltransferase deficiency and heterozygosity among patients intolerant to mercaptopurine or azathioprine J Clin Oncol 19 2293-3995

[3] Evans WE(2015)Inherited genetic variation in childhood acute lymphoblastic leukemia Blood 125 3988-2008

[4] Moriyama T(1999)Mercaptopurine therapy intolerance and heterozygosity at the thiopurine S-methyltransferase gene locus J Natl Cancer Inst 91 2001-325

[5] Relling MV(2013)Clinical pharmacogenetics implementation consortium guidelines for thiopurine methyltransferase genotype and thiopurine dosing: 2013 update Clin Pharmacol Ther 93 324-195

[6] Yang JJ(2002)Molecular analysis of thiopurine S-methyltransferase alleles in South-east Asian populations Pharmacogenetics 12 191-70

[7] Relling MV(2004)Thiopurine S-methyltransferase genetic polymorphism in the Thai population Br J Clin Pharmacol 58 66-564

[8] Relling MV(2012)The activity of the inosine triphosphate pyrophosphatase affects toxicity of 6-mercaptopurine during maintenance therapy for acute lymphoblastic leukemia in Japanese children Leuk Res 36 560-1020

[9] Chang JG(2014)A common missense variant in NUDT15 confers susceptibility to thiopurine-induced leukopenia Nat Genet 46 1017-e26

[10] Srimartpirom S(2016)NUDT15 c.415C > T increases risk of 6-mercaptopurine induced myelosuppression during maintenance therapy in children with acute lymphoblastic leukemia Haematologica 101 e24-614