Genetic testing and surgical decision making in hereditary colorectal cancer

被引：0

作者：

C. Soravia

T. Berk

Z. Cohen

机构：

[1] Clinique de Chirurgie Digestive,

[2] Geneva University Hospital,undefined

[3] Rue Micheli-du-Crest 24,undefined

[4] 1211 Geneva 14,undefined

[5] Switzerland e-mail: Claudio.Soravia@hcuge.ch Tel.: +41-22-3727705 Fax: +41-22-3727707,undefined

[6] Registre des Pathologies Héréditaires Digestives,undefined

[7] Geneva University Hospital,undefined

[8] Rue Micheli-du-Crest 24,undefined

[9] 1211 Geneva 14,undefined

[10] Switzerland,undefined

[11] Department of Surgery,undefined

[12] Mount Sinai Hospital,undefined

[13] University of Toronto,undefined

[14] 600 University Avenue,undefined

[15] Toronto,undefined

[16] Ontario M5G 1X5,undefined

[17] Canada,undefined

[18] Familial Gastrointestinal Cancer Registry,undefined

[19] Mount Sinai Hospital,undefined

[20] University of Toronto,undefined

[21] 600 University Avenue,undefined

[22] Toronto,undefined

[23] Ontario M5G 1X5,undefined

[24] Canada,undefined

来源：

International Journal of Colorectal Disease | 2000年 / 15卷

关键词：

Keywords Genetic testing; Familial adenomatous polyposis; Hereditary nonpolyposis colorectal cancer; Juvenile polyposis; Peutz-Jeghers syndrome; Surgical decision making;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Hereditary colorectal cancer results from specific genetic alterations. The causative genes for familial adenomatous polyposis, juvenile polyposis, Peutz-Jeghers syndrome, and hereditary nonpolyposis colorectal cancer have been cloned and characterized within the past decade. Genetic testing has therefore become more widely used to confirm the clinical diagnosis of each of those syndromes, to provide adequate surveillance, to allow screening of at-risk family members, and to help the surgeon in surgical decision making. The aim of this review is to analyze the importance of genetic testing in view of the clinical and surgical management of those gene-carriers individuals, and to discuss how should the surgeon integrate genetic testing in the evaluation of such patients.

引用

页码：21 / 28

页数：7

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