The evidence for fungus in Crohn’s disease pathogenesis

被引：26
作者：
Miyoshi J. [1 ]
Sofia M.A. [1 ]
Pierre J.F. [2 ]
机构：
[1] Section of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, The University of Chicago, Chicago
[2] Department of Pediatrics, The University of Tennessee Health Science Center, 425 Translational Research Building, 71 South Manassas, Memphis, 38163, TN
来源：
Clinical Journal of Gastroenterology | 2018年 / 11卷 / 6期
关键词：
Crohn’s disease; Fungal pathogens; Inflammatory bowel diseases; Microbiome; Mycobiome;
D O I：
10.1007/s12328-018-0886-9
中图分类号：
学科分类号：
摘要：
Current evidence suggests the etiology of inflammatory bowel diseases (IBD) involves the confluence of host genetic, environmental, and microbial factors that lead to chronic, and often refractory, disease in susceptible individuals. The involvement of microbial triggers in IBD, including Crohn’s disease (CD), is increasingly evident with supporting data provided with advancements in metagenomic sequencing that have identified perturbations in microbial structure and function—broadly termed dysbiosis—in CD patients compared with healthy subjects. This concept is supported by the finding germ-free animals with CD genetic susceptibility fail to develop disease; demonstrating microorganisms are necessary but not sufficient for CD. The vast majority of CD microbiome research has focused on the complex bacterial communities and microbiome dysbiosis in the gut with 16S metagenomic sequencing. However, emerging data capturing eukaryotes suggest fungal opportunistic pathogens are also associated with IBD pathogenesis and chronicity. This hypothesis is further supported by historical observations that CD patient populations display elevated antibodies against fungal targets, even evident before disease diagnosis. This review discusses the current findings in the field, followed by historical and metagenomic evidence for fungal pathogens in the development and recurrence of CD in adult and pediatric populations. © 2018, Japanese Society of Gastroenterology.
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页码：449 / 456
页数：7
相关论文
共 78 条
[1]  
Ng S.C., Shi H.Y., Hamidi N., Et al., Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies, Lancet, 390, pp. 2769-2778, (2018)
[2]  
Mesbah-Uddin M., Elango R., Banaganapalli B., Et al., In-silico analysis of inflammatory bowel disease (IBD) GWAS loci to novel connections, PLoS One, 10, (2015)
[3]  
Jostins L., Ripke S., Weersma R.K., Et al., Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease, Nature, 491, pp. 119-124, (2012)
[4]  
Mukherjee P.K., Sendid B., Hoarau G., Et al., Mycobiota in gastrointestinal diseases, Nat Rev Gastroenterol Hepatol, 12, pp. 77-87, (2015)
[5]  
Scharl M., Rogler G., Microbial sensing by the intestinal epithelium in the pathogenesis of inflammatory bowel disease, Int J Inflam, 2010, (2010)
[6]  
Ward M.A., Pierre J.F., Leal R.F., Et al., Insights into the pathogenesis of ulcerative colitis from a murine model of stasis-induced dysbiosis, colonic metaplasia, and genetic susceptibility, Am J Physiol Gastrointest Liver Physiol, 310, pp. G973-G988, (2016)
[7]  
Goodwin S., McPherson J.D., McCombie W.R., Coming of age: ten years of next-generation sequencing technologies, Nat Rev Genet, 17, pp. 333-351, (2016)
[8]  
Caporaso J.G., Kuczynski J., Stombaugh J., Et al., QIIME allows analysis of high-throughput community sequencing data, Nat Methods, 7, pp. 335-336, (2010)
[9]  
Schloss P.D., Westcott S.L., Ryabin T., Et al., Introducing mothur: open-source, platform-independent, community-supported software for describing and comparing microbial communities, Appl Environ Microbiol, 75, pp. 7537-7541, (2009)
[10]  
Lee C.K., Herbold C.W., Polson S.W., Et al., Groundtruthing next-gen sequencing for microbial ecology-biases and errors in community structure estimates from PCR amplicon pyrosequencing, PLoS One, 7, (2012)
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