Genetic analysis of variation in transcription factor binding in yeast

被引：0
作者：
Wei Zheng
Hongyu Zhao
Eugenio Mancera
Lars M. Steinmetz
Michael Snyder
机构：
[1] Cellular and Developmental Biology,Department of Molecular
[2] Yale University,Department of Epidemiology and Public Health
[3] Program in Computational Biology and Bioinformatics,Department of Genetics
[4] Yale University,undefined
[5] ,undefined
[6] Yale University School of Medicine,undefined
[7] New Haven,undefined
[8] Connecticut 06520,undefined
[9] USA,undefined
[10] Genome Biology Unit,undefined
[11] European Molecular Biology Laboratory,undefined
[12] Stanford University School of Medicine,undefined
[13] Stanford,undefined
[14] California 94305,undefined
[15] USA,undefined
[16] Present address: Biostatics Resources,undefined
[17] Keck Laboratory,undefined
[18] Yale University,undefined
[19] New Haven,undefined
[20] Connecticut 06520,undefined
[21] USA.,undefined
来源：
Nature | 2010年 / 464卷
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摘要：
Many, possibly most phenotypic differences among individuals arise from differences in gene expression and the underlying transcriptional regulation. Zheng et al. studied the variability of transcription factor binding among individuals on a genome-wide scale, using transcription-binding variability as a genetic trait for QTL (quantitative trait locus) mapping. Taking a well-known yeast transcription factor in the yeast pheromone pathway as an example, they mapped the underlying loci responsible for variation. The study revealed novel insights into mechanisms of gene regulation as well as new regulators of the pheromone pathway in yeast.
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页码：1187 / 1191
页数：4
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