Direct comparison study between FDG-PET and IMP-SPECT for diagnosing Alzheimer's disease using 3D-SSP analysis in the same patients

被引：26

作者：

Nihashi T. ^{[1
]}

Yatsuya H. ^{[2
]}

Hayasaka K. ^{[1
]}

Kato R. ^{[1
]}

Kawatsu S. ^{[3
]}

Arahata Y. ^{[4
]}

Iwai K. ^{[4
]}

Takeda A. ^{[4
]}

Washimi Y. ^{[4
]}

Yoshimura K. ^{[5
]}

Mizuno K. ^{[5
]}

Kato T. ^{[5
]}

Naganawa S. ^{[6
]}

Ito K. ^{[5
]}

机构：

[1] Department of Radiology, National Center for Geriatrics and Gerontology, Ohbu 474-8522, 36-3 Gengo, Morioka-Cho

[2] Department of Pubic Health, Nagoya University School of Medicine, Nagoya

[3] Department of Radiology, Kyoritsu General Hospital, Nagoya

[4] Department of Neurology, National Center for Geriatrics and Gerontology, Ohbu

[5] Department of Brain Science and Molecular Imaging, National Center for Geriatrics and Gerontology, Ohbu

[6] Department of Radiology, Nagoya University Graduate School of Medicine, Nagoya

来源：

Radiation Medicine | 2007年 / 25卷 / 6期

关键词：

3D-SSP; Alzheimer's disease; PET; SPECT;

D O I：

10.1007/s11604-007-0132-8

中图分类号：

学科分类号：

摘要：

Purpose. The purpose of this study was to evaluate and compare the diagnostic ability of 2-[18F]-fluoro-2-deoxy-d-glucose (FDG) positron emission tomography (PET) and N-isopropyl-p-123I iodoamphetamine single photon emission computed tomography (IMP-SPECT) using three-dimensional stereotactic surface projections (3D-SSP) in patients with moderate Alzheimer's disease (AD). Materials and methods. FDG-PET and IMP-SPECT were performed within 3 months in 14 patients with probable moderate AD. Z-score maps of FDG-PET and IMP-SPECT images of a patient were obtained by comparison with data obtained from control subjects. Four expert physicians evaluated and graded the glucose hypometabolism and regional cerebral blood flow (rCBF), focusing in particular on the posterior cingulate gyri/precunei and parietotemporal regions, and determined the reliability for AD. Receiver operating characteristic (ROC) curves were applied to the results for clarification. To evaluate the correlation between two modalities, the regions of interest (ROIs) were set in the posterior cingulate gyri/precunei and parietotemporal region on 3D-SSP images, and mean Z-values were calculated. Conclusion. No significant difference was observed in the area under the ROC curve (AUC) between FDG-PET and IMP-SPECT images (FDG-PET 0.95, IMP-SPECT 0.94). However, a significant difference (P < 0.05) was observed in the AUC for the posterior cingulate gyri/precuneus (FDG-PET 0.94, IMP-SPECT 0.81). The sensitivity and specificity of each modality were 86%, and 97% for FDG-PET and 70% and 100% for IMP-SPECT. We could find no significant difference between FDG-PET and IMP-SPECT in terms of diagnosing moderate AD using 3D-SSP. There was a high correlation between the two modalities in the parietotemporal region (Spearman's r = 0.82, P < 0.001). The correlation in the posterior cingulate gyri/precunei region was lower than that in the parietotemporal region (Spearman's r = 0.63, P < 0.016). © 2007 Japan Radiological Society.

引用

页码：255 / 262

页数：7

共 28 条

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