Protective effect of Lycium barbarum polysaccharide on di-(2-ethylhexyl) phthalate-induced toxicity in rat liver

被引：0
作者：
Rui-jing Liu
Yong-jian He
Huan Liu
Dong-dong Zheng
Shao-wen Huang
Chun-hong Liu
机构：
[1] South China Agricultural University,Guangdong Provincial Key Laboratory of Food Quality and Safety, College of Food Science
[2] Ministry of Agriculture,Laboratory of Quality and Safety Risk Assessment to Post
来源：
Environmental Science and Pollution Research | 2021年 / 28卷
关键词：
Di-(2-ethylhexyl) phthalate; polysaccharide; Pregnane X receptor; Detoxifying enzymes;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Di-(2-ethylhexyl)-phthalate (DEHP) is the most commonly used plasticizer and it has been a ubiquitous environmental contaminant which affects health. The purpose of this study was to investigate the protective effect of the Lycium barbarum polysaccharide (LBP) at dosages of 100, 200, and 300 mg/kg bw on DEHP-induced (3000 mg/kg) toxicity in rat liver through a 28-day animal experiment. The results showed that LBP attenuated oxidative stress slightly by lowering the production of ROS and improving the activity of SOD and GSH-Px in liver and serum of DEHP treatment rats. At the same time, the levels of PXR, CYP450, CYP2E1, CYP3A1, UGT1, and GST were reduced after LBP treatment. Moreover, LBP decreased the mRNA expression of PXR, UGT1, and GST significantly. These findings suggested that LBP might ameliorate DEHP-induced liver injury by down-regulating the expression of PXR in liver, further down-regulating the downstream phase I and II detoxification enzymes, thus reducing the damage caused by DEHP. Therefore, LBP may have the potential to become an auxiliary therapeutic agent as a natural ingredient of health food.
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页码：23501 / 23509
页数：8
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